Energy-restricted Central-European diet stimulates liver microsomal function in obese postmenopausal women – a randomized nutritional trial with a comparison to energy-restricted Mediterranean diet
M Szczepanik, I J Malesza, J Bajerska, A Chmurzyńska, A Muzsik, S Bermagambetova, E Mądry, J Walkowiak, A Lisowska
Objective: Obesity and metabolic syndrome are risk factors for liver diseases like non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. A healthy food pattern is vital for managing these health problems, therefore, this study investigated how two calorie-restricted diets, the Central European diet (CED) and Mediterranean diet (MED), altered microsomal liver function in obese postmenopausal women with a risk of metabolic syndrome.
Patients and methods: One-hundred-forty-four subjects were randomly assigned to the CED (n=72) or the MED (n=72) groups. A 13C-methacetin breath test was performed, before and after the intervention to assess CPDR (Cumulative Percentage Dose Recovery at 120 minutes of the test), TTP (Time to Peak – maximal momentary recovery of 13C) and Vmax (the maximum momentary 13C recovery).
Results: There was a statistically significant increase in TTP and Vmax in the CED group only (p=0.0159 and p=0.0498, respectively). Changes in CPDR and TTP due to intervention were significantly higher in the CED group than in the MED group (p=0.0440 and p=0.0115, respectively).
Conclusions: This is the first study to document a stimulatory effect of the energy-restricted CED on liver microsomal function as compared to MED. The relatively short dietary intervention led to a significant difference in the CYP1A2 activity between groups. The trial was registered in the German Clinical Trials Register (DRKS-ID: DRKS00012958; URL: https://www.germanctr.de/).
Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11165-11171. doi: 10.26355/eurrev_202011_23604. PMID: 33215434.
https://pubmed.ncbi.nlm.nih.gov/33215434/
