Influence of supplementation with iron and probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of inflammatory state in rats on a high-fat iron-deficient diet<\/p>\n
Katarzyna Skrypnik, a, Marcin Schmidt, b, Agnieszka Olejnik-Schmidt, b, Iskandar Azmy Harahap, a and Joanna Suliburska, a<\/p>\n
a Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poznan, Poland<\/p>\n
b Department of Food Biotechnology and Microbiology, Poznan University of Life Sciences, Poznan, Poland<\/p>\n
Abstrakt<\/p>\n
BACKGROUND: A high-fat (HF) diet, diet iron deficiency and iron supplementation may affect inflammatory parameters. Probio- tics influence both iron metabolism and inflammation. We compared the inflammatory state in rats on a HF iron-deficient diet receiving oral iron, Lactobacillus plantarum and Lactobacillus curvatus in different combinations.<\/p>\n
METHODS: This was a two-stage experiment. In groups C (n = 8) and HF (n = 8), rats ate a control or HF diet, respectively, for 16 weeks. In the group HFDEF (n = 48), rats ate a HF iron-deficient diet for 8 weeks (first stage) and were subsequently divided into 6 groups (n = 8 each) receiving the following for a further 8 weeks (second stage): HFDEF \u2013 a HF iron-deficient diet; HFDEFFe \u2013 a HF iron-deficient diet with iron; HFDEFLp and HFDEFLc \u2013 a HF iron-deficient diet with L. plantarum or L. curvatus, respectively; and HFDEFFeLp and HFDEFFeLc \u2013 a HF iron-deficient diet with iron and L. plantarum or L. curvatus, respectively. Body composition analysis and blood sampling was performed. Markers of iron status and levels of total antiox- idant status (TAS), C-reactive protein (CRP), tumour necrosis factor alpha (TNF-\u228d) and interleukin 6 (IL-6) were measured in the blood.<\/p>\n
RESULTS: TAS was higher in the HFDEF group (756.57 \u00b1 489.53 ng mL\u22121 ) versus the HFDEFLc group (187.04 \u00b1 47.84 ng mL\u22121 ; P = 0.022). No more differences were found between groups, or in TAS, CRP, TNF-\u228d and IL-6 concentrations. Also, no differences were found between groups for alanine and aspartate aminotransferases, glucose, total cholesterol, low- and high-density lipo- proteins and triglycerides. TAS level was positively correlated with ferritin concentration, IL-6 with TAS and TNF-\u228d with hepci- din level.<\/p>\n
CONCLUSIONS: Supplementation with L. plantarum, L. curvatus and iron in combinations exerts no influence on inflammatory status, lipid profile, hepatic function and serum fasting glucose in rats on a HF iron-deficient diet.<\/p>\n
S\u0142owa kluczowe: iron; probiotics; inflammatory status; iron-deficient diet<\/p>\n
J Sci Food Agric 2024<\/p>\n","protected":false},"excerpt":{"rendered":"
Influence of supplementation with iron and probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of inflammatory state in rats on a high-fat iron-deficient diet Katarzyna Skrypnik, a, Marcin Schmidt, b, Agnieszka Olejnik-Schmidt, b, Iskandar Azmy Harahap, a and… Czytaj dalej<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[20],"tags":[],"_links":{"self":[{"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/posts\/1892"}],"collection":[{"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/comments?post=1892"}],"version-history":[{"count":1,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/posts\/1892\/revisions"}],"predecessor-version":[{"id":1893,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/posts\/1892\/revisions\/1893"}],"wp:attachment":[{"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/media?parent=1892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/categories?post=1892"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/tags?post=1892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}