{"id":1184,"date":"2020-11-24T14:32:14","date_gmt":"2020-11-24T13:32:14","guid":{"rendered":"http:\/\/www1.up.poznan.pl\/kzcid\/?p=1184"},"modified":"2020-11-24T14:32:14","modified_gmt":"2020-11-24T13:32:14","slug":"nowa-publikacja-3","status":"publish","type":"post","link":"http:\/\/www1.up.poznan.pl\/kzcid\/bez-kategorii-pl\/nowa-publikacja-3\/","title":{"rendered":"Nowa publikacja"},"content":{"rendered":"<p><strong>Energy-restricted Central-European diet stimulates liver microsomal function in obese postmenopausal women &#8211; a randomized nutritional trial with a comparison to energy-restricted Mediterranean diet<\/strong><\/p>\n<p>M Szczepanik, I J Malesza, J Bajerska, A Chmurzy\u0144ska, A Muzsik, S Bermagambetova, E M\u0105dry, J Walkowiak, A Lisowska<\/p>\n<p><strong class=\"sub-title\">Objective:\u00a0<\/strong>Obesity and metabolic syndrome are risk factors for liver diseases like non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. A healthy food pattern is vital for managing these health problems, therefore, this study investigated how two calorie-restricted diets, the Central European diet (CED) and Mediterranean diet (MED), altered microsomal liver function in obese postmenopausal women with a risk of metabolic syndrome.<\/p>\n<p><strong class=\"sub-title\">Patients and methods:\u00a0<\/strong>One-hundred-forty-four subjects were randomly assigned to the CED (n=72) or the MED (n=72) groups. A 13C-methacetin breath test was performed, before and after the intervention to assess CPDR (Cumulative Percentage Dose Recovery at 120 minutes of the test), TTP (Time to Peak &#8211; maximal momentary recovery of 13C) and Vmax (the maximum momentary 13C recovery).<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>There was a statistically significant increase in TTP and Vmax in the CED group only (p=0.0159 and p=0.0498, respectively). Changes in CPDR and TTP due to intervention were significantly higher in the CED group than in the MED group (p=0.0440 and p=0.0115, respectively).<\/p>\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>This is the first study to document a stimulatory effect of the energy-restricted CED on liver microsomal function as compared to MED. The relatively short dietary intervention led to a significant difference in the CYP1A2 activity between groups. The trial was registered in the German Clinical Trials Register (DRKS-ID: DRKS00012958; URL: https:\/\/www.germanctr.de\/).<\/p>\n<p>Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11165-11171. doi: 10.26355\/eurrev_202011_23604. PMID: 33215434.<\/p>\n<p>https:\/\/pubmed.ncbi.nlm.nih.gov\/33215434\/<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Energy-restricted Central-European diet stimulates liver microsomal function in obese postmenopausal women &#8211; a randomized nutritional trial with a comparison to energy-restricted Mediterranean diet M Szczepanik, I J Malesza, J Bajerska, A Chmurzy\u0144ska, A Muzsik, S Bermagambetova, E M\u0105dry, J Walkowiak,&hellip;&nbsp;<a href=\"http:\/\/www1.up.poznan.pl\/kzcid\/bez-kategorii-pl\/nowa-publikacja-3\/\" class=\"more-link\">Czytaj dalej<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[20,14],"tags":[],"_links":{"self":[{"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/posts\/1184"}],"collection":[{"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/comments?post=1184"}],"version-history":[{"count":1,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/posts\/1184\/revisions"}],"predecessor-version":[{"id":1190,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/posts\/1184\/revisions\/1190"}],"wp:attachment":[{"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/media?parent=1184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/categories?post=1184"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www1.up.poznan.pl\/kzcid\/wp-json\/wp\/v2\/tags?post=1184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}